A continuation of Flad's 2016 presentation about life cycle-driven master planning, this case study examines the reuse of an existing historic structure facing radical technological change. Building construction technologies have advanced since Mudd Hall was built on the campus of Northwestern University in the 1970s, as have research environments. The presentation will examine sustainable redevelopment and renovation, as well as applying high-tech design to high-tech research. The presentation will provide lessons learned while navigating a number of design challenges, and session leaders will provide tools and metrics to help research facility managers understand the decision-making process, helping them reduce construction and operational costs, and be responsible stewards of their research campuses and organizations.